Description

Casein Kinase 2 Substrate is a specialized synthetic peptide sequence designed for the study and characterization of Casein Kinase 2 (CK2) activity. This compound serves as a critical tool for researchers investigating cellular signaling pathways, protein phosphorylation, and enzyme kinetics. It is essential for biochemical assays, drug discovery screening, and fundamental research in molecular biology and oncology. The product is supplied as a high-purity, lyophilized powder to ensure reliable and reproducible experimental results.

Application

This peptide substrate is utilized in a variety of research and development contexts, primarily within life sciences and pharmaceutical development.

• Enzyme Activity Assays: Primary substrate for in vitro quantification of Casein Kinase 2 (CK2) activity and inhibition studies.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) platforms to identify and characterize novel CK2 inhibitors as potential therapeutic agents.
• Biochemical Research: Fundamental tool for studying phosphorylation mechanisms, substrate specificity, and kinetic parameters of CK2.
• Diagnostic Development: Potential component in developing assays for monitoring CK2 activity levels in clinical research samples.
• Academic & Industrial R&D: Critical reagent for laboratories in universities, research institutes, and biopharmaceutical companies focused on signal transduction.

Basic Information

Product Name	Casein Kinase 2 Substrate
CAS No.	95651-74-4
Molecular Formula	C44H71N13O12
Molecular Weight	950.1 g/mol
Synonyms	CK2 Substrate Peptide; Casein Kinase II Substrate; RRREEETEEE; Arg-Arg-Arg-Glu-Glu-Glu-Thr-Glu-Glu-Glu; RRRADDSDDD; Phosphoacceptor Peptide for CK2; CK2tide (common alias)
EINECS	Contact for details

Quality Control

Our Casein Kinase 2 Substrate is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, peptide content, and solubility data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Solubility	Soluble in water or aqueous buffer
Single Spot on TLC	One major spot

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.