Description

n-T-Boc-(D-Ala2,n-Me-p-Nitro-Phe4,Gly5-Ol)-Enkephalin is a chemically modified, synthetic pentapeptide analog of the endogenous opioid peptide enkephalin. This compound is of significant value in pharmaceutical research and development, particularly for studying opioid receptor interactions, structure-activity relationships (SAR), and as a key intermediate in the synthesis of novel peptide-based therapeutics. It is primarily needed by research institutions, pharmaceutical companies, and biotechnology firms engaged in neuropharmacology, pain management research, and peptide drug discovery.

Application

• Neuroscience Research: A critical tool for investigating the function and binding mechanisms of opioid receptors in the central nervous system.
• Drug Discovery Intermediate: Serves as a key building block in the synthesis of novel peptide-based analgesics and therapeutic agents targeting pain pathways.
• Structure-Activity Relationship (SAR) Studies: Used to elucidate the impact of specific amino acid modifications (D-Ala, N-methylation, p-Nitro-Phe) on peptide potency, selectivity, and metabolic stability.
• Biochemical Assay Standard: Employed as a reference standard in competitive binding assays and functional assays to characterize new compounds.
• Peptide Chemistry & Conjugation: The tert-butyloxycarbonyl (Boc) protecting group allows for selective deprotection and further chemical conjugation or solid-phase peptide synthesis (SPPS) elongation.

Basic Information

Product Name	n-T-Boc-(D-Ala2,n-Me-p-Nitro-Phe4,Gly5-Ol)-Enkephalin
CAS No.	95537-08-9
Molecular Formula	C33H45N7O11
Molecular Weight	715.75 g/mol
Synonyms	Boc-Tyr-D-Ala-Gly-N-Me-p-nitrophenylalanyl-glycinol; Boc-[D-Ala2, N-Me-Phe(4-NO2)4, Gly-ol5]-Enkephalin; H-Tyr-D-Ala-Gly-N-Me-Phe(p-NO2)-Gly-ol, Nα-Boc-protected; [D-Ala2, N-Me-Phe(4-NO2)4, Gly-ol5]-Enkephalin, N-T-Boc-; Modified Enkephalin Analog; Opioid Receptor Peptide Ligand; Boc-Enkephalin Amide Derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of n-T-Boc-(D-Ala2,n-Me-p-Nitro-Phe4,Gly5-Ol)-Enkephalin is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We adhere to cGMP guidelines for the production of research-grade bioactive peptides.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.