Description

Fasciculin Ii CAS NO 95506-56-2 is a potent, naturally occurring polypeptide toxin isolated from the venom of the green mamba snake (*Dendroaspis angusticeps*). It functions as a highly selective, irreversible inhibitor of acetylcholinesterase (AChE), making it a critical tool for neurological and pharmacological research. This compound is essential for scientists and institutions studying cholinergic signaling, enzyme kinetics, and the development of novel therapeutic agents. Its high specificity and potency provide invaluable insights into the structure and function of AChE and related biological pathways.

Application

• Neurological Research: Used as a specific probe to study the role and inhibition of acetylcholinesterase in synaptic transmission and neurodegenerative disease models.
• Enzyme Kinetics Studies: Employed to investigate the binding mechanisms, catalytic activity, and inhibition kinetics of AChE isoforms.
• Pharmacological Development: Serves as a reference standard and tool compound in the discovery and screening of new anticholinesterase drugs or antidotes.
• Toxicology & Venom Research: A key component for studying the biochemical effects and mechanisms of snake venom toxins.
• Biochemical Assay Standard: Used to calibrate and validate assays designed to measure AChE activity in various biological samples.
• Structural Biology: Aids in crystallographic and molecular modeling studies to understand AChE-inhibitor interactions at the atomic level.

Basic Information

Product Name	Fasciculin Ii
CAS No.	95506-56-2
Molecular Formula	C184H282N56O53S7
Molecular Weight	Approx. 4370.9 g/mol
Synonyms	Fasciculin 2; Fasciculin-2; FAS2; Dendroaspis angusticeps toxin; Acetylcholinesterase inhibitor FAS-II; Mamba fasciculin II; FAS II; Polypeptide FII; AChE inhibitor peptide FASC2; Snake venom toxin FAS2
EINECS	Contact for details

Quality Control

Our Fasciculin Ii is produced and handled under stringent conditions to ensure the highest standards of purity and biological activity, suitable for advanced research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, potency, and identity verification. We adhere to rigorous in-house quality protocols to guarantee batch-to-batch consistency and reliability for your critical research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Biological Activity (AChE Inhibition Assay)	≥ 98% of reference standard
Water Content (Karl Fischer)	≤ 5.0 %
Endotoxin Level (LAL Test)	< 1.0 EU/µg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.