Description

Neurotensin, Azidobenzoyl-Lys(6)-Trp(11)- is a chemically modified neurotensin peptide analog designed for advanced biochemical research and pharmaceutical development. This compound is engineered to serve as a versatile tool for receptor binding studies, photolabeling, and targeted drug delivery applications due to its incorporated azidobenzoyl group. It is primarily utilized by researchers and developers in the fields of neuroscience, oncology, and peptide-based therapeutic discovery who require high-purity, well-characterized bioactive peptides.

Application

• Photolabeling and Receptor Mapping: Used to covalently label and identify neurotensin receptor subtypes (NTSR1, NTSR2) in biological systems for structural and functional studies.
• Bioconjugation and Probe Development: Serves as a key intermediate for creating fluorescent, radioactive, or affinity-tagged probes via click chemistry, facilitated by the azido functional group.
• Drug Targeting Research: Investigated for the development of targeted therapeutics that leverage neurotensin receptor overexpression in certain cancers, such as pancreatic and colon cancer.
• Signal Transduction Studies: Employed to elucidate downstream signaling pathways activated by neurotensin receptors, including G-protein coupling and β-arrestin recruitment.
• In Vitro and Ex Vivo Assays: Used in competitive binding assays, autoradiography, and cell-based functional assays to screen for receptor agonists or antagonists.
• Peptide-Drug Conjugate (PDC) Synthesis: Acts as a targeting moiety in the design of novel peptide-drug conjugates for enhanced specificity and reduced off-target effects.

Basic Information

Item	Details
Product Name	Neurotensin, Azidobenzoyl-Lys(6)-Trp(11)-
CAS No.	95051-06-2
Molecular Formula	C₉₀H₁₂₈N₂₈O₂₀
Molecular Weight	~1978.2 g/mol
Synonyms	Azidobenzoyl-Neurotensin (6-13); Nε-Azidobenzoyl-Lys6, Trp11-Neurotensin; Neurotensin (6-13), Azidobenzoyl-Lys(6)-Trp(11)-; NT(6-13) AzBz-Lys(6)-Trp(11); Photoreactive Neurotensin Analog; Neurotensin Receptor Photoaffinity Label; p-Azidobenzoyl-NT(6-13); NTS Azido Derivative
EINECS	Contact for details

Quality Control

Our Neurotensin, Azidobenzoyl-Lys(6)-Trp(11)- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous in-process controls and final release testing protocols. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Assay (Peptide Content)	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%
Solubility	Soluble in DMSO, Acetonitrile/Water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.