Description

Proline, 4-(2-Hydroxy-1-Methylethyl)- (6Ci,9Ci) is a specialized, non-proteinogenic proline derivative, offering a unique chiral scaffold with a hydroxymethylethyl side chain. This structural feature makes it a valuable building block for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for creating novel peptide mimetics, active pharmaceutical ingredients (APIs), and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in oncology and metabolic disease research.
• Peptidomimetic Design: Used to introduce conformational constraints and enhance the metabolic stability of peptide-based therapeutics.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in stereoselective organic synthesis for fine chemicals.
• Biochemical Research: Employed in studies of enzyme inhibition, receptor binding, and other structure-activity relationship (SAR) investigations.
• Agrochemical Development: Potential use as an intermediate in the synthesis of advanced, chiral crop protection agents.

Basic Information

Product Name	Proline, 4-(2-Hydroxy-1-Methylethyl)- (6Ci,9Ci)
CAS No.	95047-04-4
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	4-(2-Hydroxy-1-methylethyl)proline; 4-(1-Hydroxypropan-2-yl)proline; 4-(2-Hydroxypropyl)proline; (2S,4S)-4-(2-Hydroxy-1-methylethyl)pyrrolidine-2-carboxylic acid; L-4-(2-Hydroxypropyl)proline; Non-proteinogenic proline derivative; Hydroxyalkylproline; CAS 95047-04-4
EINECS	Contact for details

Quality Control

We supply Proline, 4-(2-Hydroxy-1-Methylethyl)- (6Ci,9Ci) in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request. We can support development projects requiring material that meets GMP or other stringent regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.