Description

Z-L-Glutamic Acid γ-Tert·Butyl Ester γ-Hydrazid CAS NO 95022-60-9 is a protected amino acid derivative, specifically a γ-hydrazide of glutamic acid with a tert-butyl ester group. This compound is a crucial building block in the synthesis of complex peptides and peptidomimetics, offering a reactive hydrazide handle for conjugation and further chemical elaboration. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic tools, and advanced biochemical probes.

Application

• Pharmaceutical Intermediate: A key synthon in the solid-phase and solution-phase synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation Chemistry: The reactive hydrazide group enables site-specific conjugation to aldehydes and ketones, useful for labeling proteins, antibodies, and other biomolecules.
• Proteomics Research: Employed in the design and synthesis of enzyme inhibitors, substrate analogs, and activity-based probes for studying protease function.
• Chemical Biology Tool Development: Used to create modified peptides for studying protein-protein interactions, signal transduction pathways, and cellular processes.
• Linker Molecule Synthesis: Serves as a versatile spacer or linker in the construction of drug delivery systems, such as antibody-drug conjugates (ADCs).
• Academic & Industrial R&D: Fundamental research reagent for exploring new synthetic methodologies and developing novel bioactive compounds.

Basic Information

Product Name	Z-L-Glutamic Acid γ-Tert·Butyl Ester γ-Hydrazid
CAS No.	95022-60-9
Molecular Formula	C₁₆H₂₃N₃O₅
Molecular Weight	337.37 g/mol
Synonyms	N-Cbz-L-glutamic acid α-tert-butyl ester γ-hydrazide; Z-Glu(OtBu)-NHNH₂; Nα-Carbobenzoxy-L-glutamic acid 1-tert-butyl ester 5-hydrazide; N-Carbobenzyloxy-L-glutamic acid γ-tert-butyl ester γ'-hydrazide; Z-L-Glu(OtBu)-NHNH₂; CBZ-Glu(OtBu)-NHNH₂; (2S)-2-[[(Benzyloxy)carbonyl]amino]-5-(2-hydrazinyl-2-oxoethoxy)-5-oxopentanoic acid tert-butyl ester; Benzyl N-[(1S)-4-(tert-butoxy)-1-[(hydrazinecarbonyl)carbamoyl]-4-oxobutyl]carbamate
EINECS	Contact for details

Quality Control

Our Z-L-Glutamic Acid γ-Tert·Butyl Ester γ-Hydrazid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, chiral analysis to confirm enantiomeric integrity, and spectroscopic identification (NMR, IR). We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring the material meets the high standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.