Description

5'-Guanylic Acid, 7-Methyl-2'-o-Methyl-, Inner Salt is a chemically modified nucleotide derivative of significant interest in advanced biochemical research and development. This compound matters for its role as a key intermediate and reference standard in the synthesis and study of modified RNA and DNA structures, particularly those relevant to epigenetic regulation and therapeutic nucleic acids. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside chemistry, oligonucleotide synthesis, and the development of mRNA-based therapeutics and diagnostics.

Application

• Biochemical Research: Serves as a critical reference standard and building block for studying RNA modification pathways and their biological functions.
• Pharmaceutical R&D: Used as an intermediate in the development and synthesis of novel therapeutic oligonucleotides, including mRNA vaccines and antisense drugs.
• Nucleoside Chemistry: A valuable precursor for the chemical synthesis of other modified nucleosides and nucleotides with tailored properties.
• Diagnostic Probe Development: Employed in the design and manufacture of labeled probes for detecting specific RNA sequences and modifications.
• Enzymology Studies: Utilized as a substrate or inhibitor to investigate the activity and specificity of methyltransferases and other RNA-modifying enzymes.
• Academic Research: Supports fundamental studies in molecular biology, genetics, and epigenetics related to post-transcriptional gene regulation.

Basic Information

Product Name	5'-Guanylic Acid, 7-Methyl-2'-o-Methyl-, Inner Salt
CAS No.	94889-79-9
Molecular Formula	C12H17N5O8P
Molecular Weight	390.27 g/mol
Synonyms	7-Methyl-2'-O-methylguanosine 5'-monophosphate; 2'-O-Methyl-7-methylguanosine 5'-phosphate; 7-Methyl-2'-O-methyl-GMP; N7-Methyl-2'-O-methylguanosine 5'-monophosphate; 2'-O-Methyl-7-methyl GMP; m7Gm-5'-P; Guanosine, 7-methyl-2'-O-methyl-, 5'-(dihydrogen phosphate), inner salt
EINECS	Contact for details

Quality Control

Our 5'-Guanylic Acid, 7-Methyl-2'-o-Methyl-, Inner Salt is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific project requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider conditions of 2-8°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.