Description

Tyr-D-Ala-Gly-Phe-D-Leu Acetate Salt is a synthetic pentapeptide derivative, specifically an acetate salt of a modified enkephalin analog. This compound is of significant interest in biochemical and pharmacological research due to its role as a potent and selective delta opioid receptor (DOP) agonist. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers involved in neuroscience, pain management research, and the development of novel therapeutic agents.

Application

• Neuroscience Research: As a key tool compound for studying delta opioid receptor (DOR) signaling pathways, function, and distribution in the central nervous system.
• Analgesic Drug Discovery: Serves as a reference standard and lead structure in the development of new, non-addictive pain relief medications targeting the delta opioid system.
• Biochemical Assays: Used in competitive binding assays (e.g., radioligand displacement) and functional assays (e.g., GTPγS) to evaluate receptor affinity and efficacy of novel compounds.
• Pharmaceutical Reference Standard: Employed for quality control, method development, and validation in analytical laboratories within the pharmaceutical industry.
• Academic Research: Fundamental studies on peptide structure-activity relationships (SAR), peptide stability, and blood-brain barrier permeability.

Basic Information

Product Name	Tyr-D-Ala-Gly-Phe-D-Leu Acetate Salt
CAS No.	94825-57-7
Molecular Formula	C34H48N6O9 • xC2H4O2
Molecular Weight	708.80 g/mol (Free base, C34H48N6O9)
Synonyms	DADLE Acetate Salt; [D-Ala2, D-Leu5]-Enkephalin Acetate; Tyr-D-Ala-Gly-Phe-D-Leu-OH Acetate; H-Tyr-D-Ala-Gly-Phe-D-Leu-OH Acetate; Delta Opioid Receptor Agonist (DADLE); (2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]-N-[(1S)-1-[[(1S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]acetamide Acetate
EINECS	Contact for details

Quality Control

Our Tyr-D-Ala-Gly-Phe-D-Leu Acetate Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing results from HPLC, MS, and NMR analyses. Production can be aligned with cGMP guidelines for advanced research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0% (by weight)
Water Content (KF)	≤ 8.0%
Acetate Content (IC)	Contact for details
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.