Description

Des-Tyr-1-Methionine Enkephalin Acetate is a synthetic peptide analog of the endogenous opioid peptide enkephalin, modified to enhance its metabolic stability and receptor selectivity. This compound is a critical research tool for studying opioid receptor pharmacology, signal transduction pathways, and the physiological roles of the endogenous opioid system. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, pain management, and neuropharmacology.

Application

• Neuroscience Research: Used as a selective ligand in receptor binding assays and functional studies to investigate δ-opioid receptor (DOR) activity and signaling.
• Pharmacological Studies: Serves as a reference standard and active agent in vitro and in vivo models to study analgesia, tolerance, and dependence mechanisms.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening (HTS) assays for drug discovery targeting the opioid system.
• Metabolic Stability Research: Acts as a model peptide to study enzymatic degradation pathways and to design peptidase-resistant therapeutic analogs.
• Academic & Educational Use: Provided as a purified compound for university-level teaching and advanced research projects in biochemistry and neurobiology.
• Preclinical Development: Used in early-stage drug development for evaluating the efficacy and pharmacokinetic profiles of novel opioid-based therapeutics.

Basic Information

Product Name	Des-Tyr-1-Methionine Enkephalin Acetate
CAS No.	94825-43-1
Molecular Formula	C26H41N7O8S • xC2H4O2
Molecular Weight	635.7 g/mol (free base)
Synonyms	Met-Enkephalin, Des-Tyrosine; [Des-Tyr¹]-Met-Enkephalin Acetate; H-Gly-Gly-Phe-Met-OH acetate; Opioid Growth Factor (OGF) analog; (Met⁵)-Enkephalin (2-5); Gly-Gly-Phe-Methionine acetate salt; YGGFM (2-5) acetate; δ-opioid receptor peptide ligand
EINECS	Contact for details

Quality Control

Every batch of Des-Tyr-1-Methionine Enkephalin Acetate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocol includes advanced chromatographic and spectroscopic methods aligned with industry best practices for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Acetate Content (IC)	1.0 - 3.0 equivalents
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.