Description

L-Leucine, Phenylmethyl Ester, Hydrobromide is a protected amino acid derivative, specifically the hydrobromide salt of L-leucine benzyl ester. This compound is a crucial chiral building block and intermediate in organic synthesis, valued for its role in constructing complex peptide structures and other bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, peptide-based drugs, and advanced chemical libraries.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected leucine residue, where the benzyl ester group serves as a temporary protecting group for the carboxylic acid functionality.
• Biochemical Research: Employed in academic and industrial R&D for studying enzyme-substrate interactions, metabolic pathways, and protein structure-activity relationships.
• Proteomics & Diagnostics: Acts as a standard or reagent in the development of analytical methods for amino acid and peptide analysis via HPLC or mass spectrometry.
• Chemical Library Development: Serves as a building block for creating diverse compound libraries used in high-throughput screening for drug discovery.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in catalytic asymmetric reactions to induce chirality in target molecules.

Basic Information

Product Name	L-Leucine, Phenylmethyl Ester, Hydrobromide
CAS No.	94787-94-7
Molecular Formula	C13H20BrNO2
Molecular Weight	302.21 g/mol
Synonyms	L-Leucine Benzyl Ester Hydrobromide; (S)-2-Amino-4-methylpentanoic Acid Benzyl Ester Hydrobromide; Benzyl L-Leucinate Hydrobromide; H-Leu-OBzl·HBr; Leucine Benzyl Ester HBr; L-Leucine Benzylester Hydrobromide; N-(Benzyloxycarbonyl)-L-leucine Hydrobromide (Note: This is a common misnomer, correct IUPAC is Benzyl L-leucinate hydrobromide)
EINECS	Contact for details

Quality Control

Our L-Leucine, Phenylmethyl Ester, Hydrobromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing specific results for assay, chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.