Description

Acetyl-D-Mannosamine, n-[Mannosamine-6-3H] is a tritium-labeled derivative of N-acetyl-D-mannosamine, a key biochemical precursor in the biosynthesis of sialic acids. This labeled compound is essential for advanced research requiring high-sensitivity detection and metabolic pathway tracing. It is primarily utilized by researchers and scientists in the fields of glycobiology, biochemistry, and pharmaceutical development for tracer studies, metabolic flux analysis, and the investigation of sialic acid-related biological processes.

Application

• Metabolic Tracer Studies: Used to trace and quantify the incorporation of mannosamine into sialic acid-containing glycoconjugates within cellular systems.
• Glycobiology Research: A critical tool for studying the biosynthesis, turnover, and function of sialylated glycoproteins and glycolipids.
• Enzyme Kinetics & Mechanism: Employed in assays to study the activity and inhibition of enzymes involved in the sialic acid pathway, such as sialyltransferases.
• Pharmaceutical R&D: Supports drug discovery efforts targeting sialic acid metabolism, relevant to areas like oncology, immunology, and infectious diseases.
• Biochemical Pathway Analysis: Enables precise tracking of metabolic flux through the hexosamine and sialic acid biosynthesis pathways.
• Autoradiography & Imaging: Serves as a radiolabeled substrate for techniques requiring high-resolution detection of sialic acid localization.

Basic Information

Product Name	Acetyl-D-Mannosamine, n-[Mannosamine-6-3H]
CAS No.	94725-25-4
Molecular Formula	C8H14NO6 * (³H)
Molecular Weight	~221.2 g/mol (unlabeled)
Synonyms	N-Acetyl-D-mannosamine-6-³H; D-Mannosamine, N-acetyl-, 6-³H-labeled; N-Acetyl-6-³H-mannosamine; 6-Tritio-N-acetyl-D-mannosamine; ManNAc-6-³H; Acetylmannosamine-6-t; N-Acetyl-6-tritio-D-mannosamine; [6-³H]-N-Acetyl-D-mannosamine
EINECS	Contact for details

Quality Control

Every batch of Acetyl-D-Mannosamine, n-[Mannosamine-6-3H] is produced and analyzed under stringent quality protocols to ensure high radiochemical purity and specific activity. Our quality assurance includes verification of identity, radiochemical purity by HPLC, and specific activity measurement. A comprehensive Certificate of Analysis (COA) detailing batch-specific results, including purity and radioactivity data, is provided with each shipment to support your research compliance and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage of radioactive materials, follow all applicable local radiation safety regulations.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (HPLC/MS)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	10-50 Ci/mmol (Contact for specific value)
Chemical Purity (HPLC)	≥ 98%
Solvent (if supplied as solution)	Ethanol:Water (Specified ratio)
Radioactivity Concentration	As per customer requirement (e.g., 1 mCi/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.