Description

Dynorphin (1-11), Pro(10)- CAS NO 94596-26-6 is a synthetic peptide fragment of the endogenous opioid peptide dynorphin A, specifically comprising the first 11 amino acids with a proline substitution at position 10. This compound is a critical research tool for investigating the κ-opioid receptor (KOR) system, its signaling pathways, and its role in neurological processes. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and biochemical researchers focused on pain modulation, addiction, and neuropsychiatric disorders.

Application

• Neuroscience Research: As a selective ligand for studying κ-opioid receptor (KOR) pharmacology, function, and distribution in the central nervous system.
• Pain Pathway Analysis: Investigation of dynorphin's complex role in pain signaling, including its potential pro-nociceptive effects and interactions with other opioid systems.
• Psychiatric Disorder Models: Research into the involvement of the dynorphin/KOR system in stress responses, depression, anxiety, and drug addiction mechanisms.
• Biochemical Assay Development: Use as a reference standard or active component in receptor binding assays, cell-based functional assays, and signal transduction studies.
• Peptide Structure-Activity Relationship (SAR) Studies: Serving as a key analog for understanding how specific amino acid modifications affect peptide stability, receptor affinity, and biological activity.
• Analytical Method Development: Acting as a high-purity calibrant for analytical techniques such as HPLC, LC-MS, and peptide mapping in quality control laboratories.

Basic Information

Product Name	Dynorphin (1-11), Pro(10)-
CAS No.	94596-26-6
Molecular Formula	C59H89N17O14
Molecular Weight	1244.45 g/mol
Synonyms	Dynorphin A (1-11), Pro10-; [Pro10]-Dynorphin A (1-11); Dynorphin A (1-11) amide, Pro10-; H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-OH; YGGFLRRIRPK; Pro10-Dynorphin 1-11; Dynorphin A 1-11 (Pro10)
EINECS	Contact for details

Quality Control

Every batch of Dynorphin (1-11), Pro(10)- is manufactured under controlled conditions and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our quality assurance protocol includes rigorous testing via HPLC, MS, and amino acid analysis. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with each order, supporting compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.