Description

Methyl 2-Ethoxy-8-Ethyl-5,8-Dihydro-5-Oxopyrido[2,3-D]Pyrimidine-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the fused pyridopyrimidine class of heterocyclic compounds. This compound is of significant commercial interest due to its role as a key synthetic building block in the research and development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for constructing complex molecular architectures with potential therapeutic activity.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly those targeting kinase inhibition and other enzymatic pathways.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new chemical entities with potential biological activity.
• Process Chemistry: Serves as a defined starting material or intermediate in the scale-up and optimization of API manufacturing processes under cGMP conditions.
• Biochemical Research: May be utilized as a tool compound or ligand in biochemical assays to study protein-ligand interactions and enzyme mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.

Basic Information

Product Name	Methyl 2-Ethoxy-8-Ethyl-5,8-Dihydro-5-Oxopyrido[2,3-D]Pyrimidine-6-Carboxylate
CAS No.	94442-14-5
Molecular Formula	C₁₃H₁₅N₃O₄
Molecular Weight	277.27 g/mol
Synonyms	Methyl 2-ethoxy-8-ethyl-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-carboxylate; 2-Ethoxy-8-ethyl-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid methyl ester; Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 2-ethoxy-8-ethyl-5,8-dihydro-5-oxo-, methyl ester; CAS 94442-14-5
EINECS	Contact for details

Quality Control

Our production of Methyl 2-Ethoxy-8-Ethyl-5,8-Dihydro-5-Oxopyrido[2,3-D]Pyrimidine-6-Carboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the exacting standards required for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.