Description

10-[3-(4-Hydroxy-1-Piperidino)Propyl]-10H-Phenothiazine-2-Carbonitrile Monomethanesulphonate is a high-purity, synthetically derived phenothiazine derivative, primarily valued as a critical pharmaceutical intermediate. Its molecular structure, featuring a phenothiazine core with a carbonitrile substituent and a piperidino-propyl side chain, makes it a key building block for advanced active pharmaceutical ingredients (APIs). This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development and synthesis of novel therapeutic agents, particularly within the central nervous system (CNS) and psychopharmacology sectors. The monomethanesulphonate salt form enhances its stability and suitability for precise formulation processes.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), especially for neurological and psychiatric medications.
• Research & Development (R&D): Used in academic and industrial laboratories for pharmacological studies, structure-activity relationship (SAR) research, and the discovery of new drug candidates.
• Chemical Synthesis: Serves as a specialized building block for constructing more complex heterocyclic compounds and fine chemicals.
• Reference Standard: Employed as a high-purity analytical standard for quality control (QC) and method validation in pharmaceutical manufacturing.

Basic Information

Product Name	10-[3-(4-Hydroxy-1-Piperidino)Propyl]-10H-Phenothiazine-2-Carbonitrile Monomethanesulphonate
CAS No.	94291-99-3
Molecular Formula	C21H24N4O5S
Molecular Weight	444.50 g/mol
Synonyms	10-[3-(4-Hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile methanesulfonate; Perphenazine Impurity; Perphenazine Related Compound; 2-Cyano-10-[3-(4-hydroxy-1-piperidinyl)propyl]phenothiazine Methanesulfonate; 10H-Phenothiazine-2-carbonitrile, 10-[3-(4-hydroxy-1-piperidinyl)propyl]-, monomethanesulfonate; Perphenazine EP Impurity B (Methanesulfonate Salt)
EINECS	Contact for details

Quality Control

Our 10-[3-(4-Hydroxy-1-Piperidino)Propyl]-10H-Phenothiazine-2-Carbonitrile Monomethanesulphonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets exacting standards for pharmaceutical R&D and intermediate use. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.