Description

Thiopropazate Dihydrochloride is a high-purity pharmaceutical intermediate and research chemical of significant importance in the development of neuroleptic agents. Its value lies in its role as a key precursor for synthesizing phenothiazine-derived compounds used in pharmacological studies. This product is essential for research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on central nervous system (CNS) drug discovery and development.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of antipsychotic and neuroleptic active pharmaceutical ingredients (APIs).
• Research & Development: Utilized in academic and industrial laboratories for pharmacological studies targeting dopamine receptors and CNS disorders.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for phenothiazine derivative production under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	Thiopropazate Dihydrochloride
CAS No.	146-28-1
Molecular Formula	C23H30Cl2N3O2S
Molecular Weight	483.47 g/mol
Synonyms	Thiopropazate HCl; 2-Chloro-10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]phenothiazine Diacetate Dihydrochloride; Dartal Dihydrochloride; Dartalan; Acetophenazine Dihydrochloride; NSC 71795; 10-[3-[4-(2-Hydroxyethyl)piperazin-1-yl]propyl]-2-(trifluoromethyl)phenothiazine Diacetate Dihydrochloride
EINECS	205-672-5

Quality Control

Our Thiopropazate Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation via FT-IR and NMR, to ensure it meets stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.