Description

(-)-Scopolamine CAS NO 138-12-5 is a high-purity, naturally occurring tropane alkaloid with significant pharmacological activity. This compound is a critical chiral building block and active pharmaceutical ingredient (API) for advanced therapeutic and research applications. It is essential for manufacturers and R&D laboratories in the pharmaceutical, biotechnology, and fine chemical synthesis sectors requiring a reliable source of this specific enantiomer.

Application

• Pharmaceutical API: Core active ingredient in antiemetic and antispasmodic medications, particularly for motion sickness and postoperative nausea.
• Transdermal Therapeutic Systems: Used in the manufacture of medicated patches for controlled, long-term delivery.
• Ophthalmic Solutions: Employed as a mydriatic and cycloplegic agent in diagnostic eye examinations and treatments.
• Pre-anesthetic Medication: Valued for its sedative and amnesic properties to reduce salivary and bronchial secretions before surgery.
• Neurological Research: A vital tool in neuroscience for studying muscarinic acetylcholine receptors and cholinergic pathways.
• Asymmetric Synthesis: Serves as a chiral precursor or resolving agent in the synthesis of complex organic molecules.

Basic Information

Product Name	(-)-Scopolamine
CAS No.	138-12-5
Molecular Formula	C17H21NO4
Molecular Weight	303.35 g/mol
Synonyms	Scopolamine; L-Scopolamine; Hyoscine; (-)-Hyoscine; Scopine Tropate; 6β,7β-Epoxy-3α-tropanyl S-(-)-tropate; Transderm-Scop® (branded form); Atrochin; Osmosin
EINECS	205-319-8

Quality Control

Our (-)-Scopolamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets stringent specifications for pharmaceutical and research use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific pharmacopoeial standards such as USP or EP.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.5%
Specific Rotation [α]20/D	-28° to -32° (c=1 in H2O)
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 1.0%
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.