Description

Clozapine CAS NO 5786-21-0 is a dibenzodiazepine derivative classified as an atypical antipsychotic agent. It is a critical active pharmaceutical ingredient (API) valued for its unique efficacy in treatment-resistant schizophrenia. This compound is essential for pharmaceutical manufacturers and research institutions developing neurological therapeutics. Its mechanism involves antagonism of dopamine and serotonin receptors, distinguishing it from typical antipsychotics.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of antipsychotic medications for schizophrenia.
• Treatment-Resistant Schizophrenia: Specifically formulated for patients who do not respond adequately to standard antipsychotic treatments.
• Neurological Research: Used as a reference standard and investigational compound in preclinical and clinical studies of dopamine and serotonin receptor pharmacology.
• Generic Drug Production: Sourced by generic pharmaceutical companies for the production of cost-effective clozapine tablets.
• Hospital Compounding: Utilized in specialized pharmacy compounding for tailored patient dosage forms.
• Analytical Standard: Serves as a high-purity standard for quality control (QC) and analytical method development in laboratories.

Basic Information

Product Name	Clozapine
CAS No.	5786-21-0
Molecular Formula	C18H19ClN4
Molecular Weight	326.83 g/mol
Synonyms	8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine; Clozaril; Leponex; Klozapol; Azaleptin; HF-1854; LX-100-129; Froidir
EINECS	227-313-6

Quality Control

Our Clozapine is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with comprehensive analysis including identity, purity, and impurity profiles. Certificates of Analysis (COA) are provided, detailing compliance with relevant pharmacopeial monographs (such as USP/EP) and in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Yellow to pale yellow, crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.