Description

L-Histidine S-Malate is a high-purity, non-hygroscopic salt form of the essential amino acid L-Histidine, offering enhanced stability and handling properties. This compound is critical for applications requiring precise biochemical activity and consistent quality, serving as a vital building block in advanced formulations. It is primarily utilized by manufacturers in the pharmaceutical, nutraceutical, and research sectors for the development of parenteral nutrition, diagnostic reagents, and high-value biochemical intermediates.

Application

• Pharmaceutical Intermediates: A key raw material in the synthesis of active pharmaceutical ingredients (APIs) and complex peptides.
• Parenteral Nutrition Solutions: An essential component in amino acid infusion formulations for clinical nutrition.
• Biochemical Research & Diagnostics: Used as a standard or reagent in enzymatic studies, cell culture media, and diagnostic kit production.
• Nutraceutical & Dietary Supplements: Incorporated into specialized supplements targeting metabolic support and recovery.
• Cosmetic Actives: Employed in advanced skincare formulations for its role in protein synthesis and skin barrier function.
• Animal Feed Additives: Used in premium feed formulations to ensure optimal growth and health in livestock.

Basic Information

Product Name	L-Histidine S-Malate
CAS No.	94231-36-4
Molecular Formula	C9H14N3O6
Molecular Weight	260.23 g/mol
Synonyms	L-Histidine Monomalate; Histidine Malate; (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid compound with (S)-hydroxybutanedioic acid; L-Histidine hydrogen (S)-malate; L-Histidine (S)-Malate Salt; H-His-OH · (S)-Malic acid; L-Histidine S-Malate Salt
EINECS	Contact for details

Quality Control

Our L-Histidine S-Malate is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and microbiological quality. Certificates of Analysis (COA) documenting compliance with relevant standards, including potential USP/EP monographs for pharmaceutical applications, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥98.5%
Specific Rotation	+10.0° to +12.0° (c=1 in H2O)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Total impurities ≤1.0%
Microbiological Control	Total Plate Count < 1000 cfu/g; Yeast & Mold < 100 cfu/g; Absence of E. coli, Salmonella

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.