Description

n-(tert-Butoxycarbonyl)-D-Methionylglycyl-4-Nitro-3-Phenyl-L-Alanyl-L-Prolinamide is a sophisticated, custom-designed peptide derivative used as a critical building block in advanced pharmaceutical research and development. This compound is valued for its role in the synthesis of complex peptide-based drug candidates, where precise stereochemistry and functional group protection are paramount. It is primarily utilized by research scientists and process chemists in the pharmaceutical and biotechnology industries for applications in medicinal chemistry, proteomics, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of novel peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological activity of peptide sequences.
• Protease Inhibitor Development: Serves as a core scaffold or intermediate in the design and synthesis of potential protease inhibitors, given its specific amino acid sequence.
• Peptide Library Synthesis: Employed in the construction of focused peptide libraries for high-throughput screening in drug discovery programs.
• Bioconjugation & Labeling Studies: The reactive and protected functional groups make it suitable for developing peptide conjugates for diagnostic or targeted delivery applications.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)-D-Methionylglycyl-4-Nitro-3-Phenyl-L-Alanyl-L-Prolinamide
CAS No.	94213-45-3
Molecular Formula	C30H44N6O8S
Molecular Weight	648.77 g/mol
Synonyms	Boc-D-Met-Gly-4-NO2-3-Ph-L-Ala-L-Pro-NH2; Boc-D-Methionylglycyl-4-nitro-3-phenyl-L-alanyl-L-prolinamide; tert-Butyloxycarbonyl-D-methionylglycyl-4-nitro-3-phenyl-L-alanyl-L-prolinamide; 94213-45-3; Boc-D-Met-Gly-(4-NO2-3-Ph)-Ala-Pro-NH2; Custom Peptide Derivative 94213-45-3; (3S)-3-[[(2S)-1-[(2S)-2-[[(2R)-2-[[(2-methylpropan-2-yl)oxycarbonyl]amino]-4-methylsulfanylbutanoyl]amino]acetyl]amino]-3-(4-nitrophenyl)-1-oxopropan-2-yl]amino]-1-(2-pyrrolidin-1-ylethylideneamino)propan-2-one (IUPAC)
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxycarbonyl)-D-Methionylglycyl-4-Nitro-3-Phenyl-L-Alanyl-L-Prolinamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request, supporting compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.