Description

2-(1-Piperazinyl)Pyrimidine Dihydrochloride is a high-purity organic salt compound, serving as a critical building block in advanced chemical synthesis. Its value lies in providing a functionalized piperazine-pyrimidine core, essential for constructing complex molecular architectures with targeted biological activity. This intermediate is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and development of novel drug candidates, especially kinase inhibitors and other small-molecule therapeutics.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemists to explore structure-activity relationships (SAR) and create new chemical entities.
• Agrochemical Synthesis: Used in the development of advanced crop protection agents and pesticides that utilize heterocyclic chemistry.
• Academic Research: Employed in university and institutional labs for studying heterocyclic compound reactivity and developing new synthetic methodologies.
• Custom Synthesis & Contract Manufacturing: A requested starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	2-(1-Piperazinyl)Pyrimidine Dihydrochloride
CAS No.	94021-22-4
Molecular Formula	C8H13N5·2HCl
Molecular Weight	268.14 g/mol
Synonyms	2-Piperazin-1-ylpyrimidine Dihydrochloride; 2-(Piperazin-1-yl)pyrimidine Dihydrochloride; 1-(Pyrimidin-2-yl)piperazine Dihydrochloride; 2-Piperazinylpyrimidine Dihydrochloride; Pyrimidine, 2-(1-piperazinyl)-, dihydrochloride; 94021-22-4; UNII-9J5C9N8V4I
EINECS	Contact for details

Quality Control

Our 2-(1-Piperazinyl)Pyrimidine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay (HPLC), residual solvents, and related substances. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.