Description

(Ac-Tyr1,D-Arg2)-Grf (1-29) Amide (Human) CAS NO 93942-91-7 is a synthetic peptide analog of Growth Hormone-Releasing Factor (GRF), specifically engineered with an N-terminal acetylation and a D-arginine substitution at position 2 to enhance its metabolic stability and biological activity. This modification is critical for research focused on growth hormone secretion, receptor binding studies, and metabolic regulation. It serves as an essential high-purity reference standard and active ingredient for pharmaceutical R&D, particularly in endocrinology and peptide-based therapeutic development.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) in the development of growth hormone secretagogues and related therapeutics.
• Endocrinology Studies: For in vitro and in vivo research investigating the mechanisms of growth hormone (GH) release, pituitary function, and metabolic pathways.
• Biochemical Assay Development: Utilized in the calibration and validation of bioassays, immunoassays, and receptor-binding studies targeting the GHRH receptor.
• Peptide Chemistry & Stability Research: Serves as a model compound for studying the effects of acetylation and D-amino acid substitutions on peptide stability, bioavailability, and pharmacokinetics.
• Academic and Institutional Research: Supplied to universities and research institutes for fundamental studies in neuroendocrinology and peptide hormone action.

Basic Information

Product Name	(Ac-Tyr1,D-Arg2)-Grf (1-29) Amide (Human)
CAS No.	93942-91-7
Molecular Formula	C149H246N44O42
Molecular Weight	3359.8 g/mol
Synonyms	Ac-Tyr1,D-Arg2-GRF(1-29)-NH2; [Ac-Tyr1, D-Arg2]-hGRF(1-29)-NH2; Growth Hormone-Releasing Factor (1-29) Amide, Human, [Ac-Tyr1,D-Arg2]-; Sermorelin Acetate analog; GHRH (1-29) analog; GRF (1-29) amide, acetylated; Growth Hormone Releasing Hormone fragment 1-29 amide; Modified GRF (1-29) NH2
EINECS	Contact for details

Quality Control

Our (Ac-Tyr1,D-Arg2)-Grf (1-29) Amide (Human) is manufactured under strict quality systems suitable for research and development applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry (MS) for identity confirmation, to ensure consistency and reliability. Certificates of Analysis (COA) detailing purity, peptide content, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate and keep frozen. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC/IC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.