Description

Ethyl L-Histidinate Dihydrochloride is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and biochemical research. This compound serves as a critical building block, offering a protected histidine side chain that is crucial for constructing peptides with specific biological activity and stability. It is primarily utilized by pharmaceutical R&D teams, peptide manufacturers, and academic research institutions focused on developing therapeutic peptides, enzyme inhibitors, and novel bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of histidine residues into peptide chains.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Biochemical Research: Employed in studies of enzyme mechanisms, receptor-ligand interactions, and metal-binding sites in proteins.
• Proteomics and Peptide Library Construction: Facilitates the synthesis of diverse peptide sequences for screening and discovery applications.
• Cosmetic Peptide Synthesis: Used in the production of bioactive peptides for advanced skincare and cosmetic formulations.
• Reference Standard: Serves as a high-purity analytical standard for quality control in peptide manufacturing.

Basic Information

Product Name	Ethyl L-Histidinate Dihydrochloride
CAS No.	93923-84-3
Molecular Formula	C8H16N3O2 · 2HCl
Molecular Weight	283.15 g/mol
Synonyms	L-Histidine ethyl ester dihydrochloride; Histidine ethyl ester dihydrochloride; H-His-OEt·2HCl; Ethyl L-histidinate hydrochloride; Ethyl (2S)-2-amino-3-(1H-imidazol-4-yl)propanoate dihydrochloride; (S)-Ethyl 2-amino-3-(1H-imidazol-4-yl)propanoate dihydrochloride; Ethyl 2-amino-3-(1H-imidazol-5-yl)propanoate dihydrochloride
EINECS	Contact for details

Quality Control

Our Ethyl L-Histidinate Dihydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including GMP-grade upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.