Description

2-Fluoro-5-Methylbenzylamine is a versatile fluorinated aromatic amine building block, essential for advanced organic synthesis. Its molecular structure, featuring both a reactive benzylamine group and a fluorine substituent, makes it a critical intermediate for introducing specific pharmacophores and modifying physicochemical properties in target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, CNS agents, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic components used in electronic displays and organic light-emitting diodes.
• Polymer Modification: Incorporated into polymer chains to alter thermal stability, solubility, and chemical resistance of high-performance engineering plastics.
• Cross-coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) for creating complex biaryl structures.
• Peptidomimetics & Bio-conjugation: The primary amine group is used for amide bond formation in peptide mimicry and for linking functional molecules in bioconjugation chemistry.

Basic Information

Product Name	2-Fluoro-5-Methylbenzylamine
CAS No.	93071-82-0
Molecular Formula	C8H10FN
Molecular Weight	139.17 g/mol
Synonyms	(2-Fluoro-5-methylphenyl)methanamine; 1-(2-Fluoro-5-methylphenyl)methanamine; 2-Fluoro-5-methylbenzenemethanamine; 2-Fluoro-5-methylbenzyl amine; 5-Methyl-2-fluorobenzylamine; α-Amino-2-fluoro-5-methyltoluene; 2-Fluoro-5-methyl-1-benzylamine
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-Methylbenzylamine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by GC/HPLC is supplied with each shipment. Our quality commitment supports compliance with cGMP and ISO 9001 standards for reliable sourcing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.