Description

(Tyr43)-Pth (43-68) (Human) is a synthetic peptide fragment corresponding to residues 43-68 of the human parathyroid hormone (PTH), with a tyrosine substitution at position 43. This compound is a critical research tool for studying the structure-activity relationships, receptor binding, and metabolic functions of PTH, a key regulator of calcium and phosphate homeostasis. It is primarily utilized by researchers and developers in the fields of endocrinology, bone metabolism, and peptide-based pharmaceutical discovery.

Application

• Biomedical Research: Used as a reference standard and active agent in studies investigating PTH signaling pathways, calcium metabolism, and bone biology.
• Receptor Binding Assays: Essential for competitive binding studies to characterize PTH receptor (PTH1R) affinity and specificity.
• Structure-Activity Relationship (SAR) Studies: The Tyr43 modification makes it a valuable probe for analyzing the impact of specific amino acid residues on PTH bioactivity.
• Antibody Production & Immunoassays: Can serve as an immunogen for generating specific antibodies or as a calibrator in ELISA and RIA development for PTH detection.
• Pharmaceutical Development: Used in preclinical research for screening and developing novel therapeutics targeting osteoporosis and disorders of mineral metabolism.
• Cell Culture & In Vitro Studies: Applied in cell-based assays to study the effects of PTH fragments on osteoblast and osteoclast activity.

Basic Information

Item	Detail
Product Name	(Tyr43)-Pth (43-68) (Human)
CAS No.	92952-95-9
Molecular Formula	C136H215N41O41
Molecular Weight	~3045.4 g/mol
Synonyms	Parathyroid Hormone (43-68) (human, Tyr43); hPTH (43-68) (Tyr43); PTH (43-68) Fragment (Human, Tyr43); [Tyr43]-hPTH (43-68); Parathyrin (43-68) fragment, 43-L-tyrosine-; [Tyr43]PTH(43-68); Synthetic human PTH fragment (43-68, Tyr43)
EINECS	Contact for details

Quality Control

Our (Tyr43)-Pth (43-68) (Human) is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical results. We adhere to rigorous quality testing protocols to meet the exacting standards required for biochemical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Analysis	Composition agrees within ±10% of theoretical
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.