Description

Ethyltyrosylarginine Methyl Ester is a synthetic tripeptide derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a crucial building block and a model substrate for studying enzyme kinetics, particularly for proteases like thrombin and trypsin. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in peptide synthesis, drug discovery, and the development of diagnostic assays.

Application

• Pharmaceutical Research: As a key intermediate and reference standard in the development of novel anticoagulant and anti-thrombotic agents.
• Enzyme Substrate: Used as a chromogenic or fluorogenic substrate for the study and quantification of serine protease activity, including thrombin, trypsin, and related enzymes.
• Biochemical Assays: Employed in high-throughput screening (HTS) platforms and diagnostic kit development for measuring protease levels in clinical and research samples.
• Peptide Chemistry: Serves as a protected peptide fragment for solid-phase or solution-phase synthesis of larger, more complex bioactive peptides.
• Academic Research: Utilized in university and institutional labs for fundamental studies on peptide-protein interactions, enzyme mechanism, and signal transduction pathways.

Basic Information

Product Name	Ethyltyrosylarginine Methyl Ester
CAS No.	92759-00-7
Molecular Formula	C21H34N6O5
Molecular Weight	450.53 g/mol
Synonyms	H-Tyr-Arg-OEt; N-(Nα-Benzyloxycarbonyl-L-tyrosyl)-Nω-nitro-L-arginine methyl ester; Z-Tyr-Arg-OMe; Ethyl N2-[(benzyloxy)carbonyl]-N5-(diaminomethylidene)-N-[1-[[1-(4-hydroxyphenyl)ethyl]amino]-1-oxo-3-phenylpropan-2-yl]-L-ornithinate; Benzyloxycarbonyl-Tyrosine-Arginine Methyl Ester; Boc-Tyr-Arg-OMe (common protected form); Thrombin substrate analog; Trypsin substrate
EINECS	Contact for details

Quality Control

Our Ethyltyrosylarginine Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.