Description

Thyrotropin-Releasing Hormone, 2-Fluoromethylimidazole- CAS NO 92484-23-6 is a fluorinated analog of the endogenous neuropeptide thyrotropin-releasing hormone (TRH), designed for enhanced metabolic stability and research utility. This modified peptide is critical for investigating the structure-activity relationships of TRH and its receptor interactions in neuroendocrine studies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, endocrinology, and peptide-based drug discovery.

Application

• Neuroscience Research: Used as a stable, fluorinated probe to study the central nervous system effects of TRH, including its potential role in arousal, cognition, and mood regulation.
• Endocrinology Studies: Employed in vitro and in vivo to investigate the hypothalamic-pituitary-thyroid (HPT) axis, thyroid-stimulating hormone (TSH) release, and related metabolic pathways.
• Peptide Drug Discovery: Serves as a key reference standard and building block in the development of novel TRH analogs with improved pharmacokinetic profiles for potential therapeutic applications.
• Biochemical Assay Development: Utilized as a ligand in receptor binding assays and functional studies to characterize TRH receptor subtypes and signaling mechanisms.
• Metabolic Stability Research: Acts as a model compound to study the impact of fluorination on peptide stability against enzymatic degradation, informing future peptide engineering.

Basic Information

Product Name	Thyrotropin-Releasing Hormone, 2-Fluoromethylimidazole- CAS NO 92484-23-6
CAS No.	92484-23-6
Molecular Formula	C16H22FN5O4
Molecular Weight	367.38 g/mol
Synonyms	2-Fluoromethylimidazole-TRH; TRH, 2-Fluoromethylimidazole-; 2-FMI-TRH; (2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-5-[(diaminomethylidene)amino]pentanoyl]-N-[(2-fluoromethyl)-1H-imidazol-5-yl]pyrrolidine-2-carboxamide; Pyroglutamyl-2-fluoromethylimidazole-histidyl-prolinamide; Fluorinated TRH Analog
EINECS	Contact for details

Quality Control

Our Thyrotropin-Releasing Hormone, 2-Fluoromethylimidazole- CAS NO 92484-23-6 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture ingress. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.