Description

Parathyroid Hormone (28-54) is a synthetic peptide fragment corresponding to the active region of the native parathyroid hormone. This high-purity compound is critical for research into calcium and phosphate metabolism, bone biology, and endocrine signaling pathways. It is an essential biochemical tool for pharmaceutical R&D, academic research, and diagnostic assay development targeting metabolic bone disorders.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of PTH receptor (PTH1R) activation, signal transduction, and downstream cellular effects.
• Drug Discovery & Development: Serves as a key pharmacophore model and intermediate in the development of novel therapeutics for osteoporosis, hypoparathyroidism, and chronic kidney disease-mineral and bone disorder (CKD-MBD).
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA, RIA) designed to measure PTH levels or related biomarkers.
• Cell Culture & In Vitro Studies: Applied to stimulate osteoblast and osteoclast activity in bone biology models to study bone formation and resorption mechanisms.
• Structure-Activity Relationship (SAR) Studies: Utilized as a core scaffold for analog synthesis to investigate the relationship between peptide structure and biological potency.

Basic Information

Product Name	Parathyroid Hormone (28-54)
CAS No.	92231-36-2
Molecular Formula	C136H220N40O39S2
Molecular Weight	3103.6 g/mol
Synonyms	PTH (28-54); Human Parathyroid Hormone (28-54); hPTH (28-54); Parathyrin (28-54); Parathormone fragment 28-54; PTH 28-54 peptide; CAS 92231-36-2
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone (28-54) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided to ensure compliance with research-grade specifications and support reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Within ±10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.