Description

Gramicidin A, Leu(5)- is a specific linear pentadecapeptide antibiotic, a defined analog of the natural gramicidin complex. This high-purity reference standard is critical for research and development in microbiology and pharmacology, offering a consistent and well-characterized tool for studying ion channel formation and antimicrobial mechanisms. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic reagents and biochemicals.

Application

• Pharmaceutical Research & Development: As a reference standard for studying the structure-activity relationships of ionophore antibiotics and their effects on bacterial cell membranes.
• Microbiological Studies: Used in research to investigate mechanisms of action against Gram-positive bacteria and to develop novel antimicrobial strategies.
• Biochemical Reagent: Employed in the formulation of specialized cell biology and biophysics research kits to modulate membrane permeability.
• Analytical Standard: Serves as a high-purity calibrant in chromatographic (HPLC, LC-MS) and spectroscopic analyses for quality control of related products.
• Ion Channel Research: A key tool for electrophysiology studies to understand the function and gating of model non-selective cation channels in lipid bilayers.

Basic Information

Product Name	Gramicidin A, Leu(5)-
CAS No.	92231-35-1
Molecular Formula	C99H140N20O17
Molecular Weight	1882.3 g/mol
Synonyms	Gramicidin A5; [Leu5]Gramicidin A; Leu(5)-Gramicidin A; Val-Gly-Ala-D-Leu-Ala-D-Val-Val-D-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-NHCH2CH2OH; Gramicidin A (Leu-5); Linear Gramicidin A Analog; Pentadecapeptide Antibiotic A5
EINECS	Contact for details

Quality Control

Our Gramicidin A, Leu(5)- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via mass spectrometry. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.