Description

2,2,6,6-Tetramethyllysine is a specialized, high-purity amino acid derivative characterized by its unique sterically hindered structure. This compound is a critical intermediate and building block in advanced organic synthesis, particularly for the development of novel pharmaceuticals and biochemical research tools. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers requiring precise molecular frameworks for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of complex drug candidates, especially those targeting neurological and metabolic pathways.
• Biochemical Research: Used as a precursor or standard in metabolic studies, enzyme inhibition assays, and proteomics research.
• Peptide Synthesis: Incorporated into custom peptides to study structure-activity relationships (SAR) due to its modified lysine side chain, which can influence peptide conformation and stability.
• Chemical Biology Probes: Acts as a foundation for creating labeled or tagged molecules used to investigate biological processes and protein interactions.
• Process Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) where its specific stereochemistry is required.

Basic Information

Product Name	2,2,6,6-Tetramethyllysine
CAS No.	92175-43-4
Molecular Formula	C10H21N2O2+
Molecular Weight	201.29 g/mol (for the cation)
Synonyms	N6,N6,N6,N6-Tetramethyl-L-lysine; L-Lysine, N6,N6,N6,N6-tetramethyl-; Tetramethyllysine; TML; (2S)-2-Amino-6-(dimethylamino)-N,N-dimethylhexan-1-aminium; 2-Amino-6-(dimethylamino)-N,N-dimethyl-1-hexanaminium (L-form); Nε,Nε,Nε,Nε-Tetramethyl-L-lysine
EINECS	Contact for details

Quality Control

Our 2,2,6,6-Tetramethyllysine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.