Description

N(3)-(1-Carboxy-2-Nitroethyl)Arginine is a specialized, non-proteinogenic amino acid derivative of significant interest in advanced biochemical research and pharmaceutical development. Its unique structure, featuring a nitroethyl moiety on the guanidino group of arginine, makes it a valuable synthetic intermediate and a tool for studying nitric oxide synthase (NOS) pathways and protein modifications. This high-purity compound is essential for researchers and manufacturers in the life sciences sector who require precise and reliable building blocks for complex molecular synthesis. Its primary utility lies in creating novel peptide analogs and investigating biochemical mechanisms related to arginine metabolism.

Application

• Pharmaceutical Research & Development: Serves as a critical synthetic intermediate in the design and synthesis of novel drug candidates, particularly those targeting nitric oxide pathways.
• Biochemical Tool Compound: Used as a substrate analog or inhibitor in enzymatic studies, specifically for research on nitric oxide synthase (NOS) isoforms and arginine-metabolizing enzymes.
• Peptide Chemistry: Acts as a modified arginine residue for the solid-phase or solution-phase synthesis of custom peptides with altered biological activity or stability.
• Proteomics & Protein Labeling: Employed in the development of chemical probes for labeling and studying post-translational modifications or protein-protein interactions.
• Academic Research: Utilized in university and institutional labs for fundamental studies in bioorganic chemistry, medicinal chemistry, and chemical biology.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	N(3)-(1-Carboxy-2-Nitroethyl)Arginine
CAS No.	92117-83-4
Molecular Formula	C9H16N5O6 • (x)H2O
Molecular Weight	Contact for details
Synonyms	NG-(1-Carboxy-2-nitroethyl)-L-arginine; 2-[(4-Amino-4-carboxybutyl)amino]-5-[(diaminomethylidene)amino]-2-nitro-5-oxopentanoic acid; Nω-(1-Carboxy-2-nitroethyl)arginine; Nδ-(1-Carboxy-2-nitroethyl)-L-arginine; L-Arginine, N3-(1-carboxy-2-nitroethyl)-; Nitroethylarginine derivative; NG-NO2Et-Arg
EINECS	Contact for details

Quality Control

Our N(3)-(1-Carboxy-2-Nitroethyl)Arginine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications and test results. Our quality commitment ensures the reproducibility and reliability required for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.