Description

ω-Conotoxin Gvia CAS NO 92078-76-7 is a highly specific, synthetic peptide toxin that selectively blocks N-type voltage-gated calcium channels (Cav2.2). This compound is a critical research tool for neuropharmacological studies, enabling the investigation of calcium channel function and neuronal signaling pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies focused on neuroscience, pain research, and the development of novel therapeutic agents.

Application

• Neuroscience Research: As a selective pharmacological probe to study the role of N-type calcium channels in synaptic transmission, neurotransmitter release, and neuronal excitability.
• Pain Pathway Analysis: Used in preclinical models to investigate the mechanisms of nociception and to validate targets for the development of new analgesic drugs.
• Ion Channel Characterization: Essential for electrophysiology studies (e.g., patch-clamp) to functionally characterize and block Cav2.2 channels in various cell types.
• Drug Discovery & Screening: Serves as a reference standard and tool compound in high-throughput screening assays for identifying new calcium channel modulators or blockers.
• Biochemical Assays: Employed in binding studies and other in vitro assays to determine receptor affinity and specificity.
• Academic & Educational Use: A key reagent for teaching advanced concepts in neurobiology and pharmacology at the university level.

Basic Information

Product Name	ω-Conotoxin Gvia
CAS No.	92078-76-7
Molecular Formula	C98H150N30O29S6
Molecular Weight	~ 2350.8 g/mol
Synonyms	ω-Conotoxin GVIA; Conotoxin GVIA; ω-Conotoxin GVIA; CgTx; SNX-124; ω-CgTx GVIA; N-type Calcium Channel Blocker; Calcium Channel Inhibitor ω-Conotoxin; ShK; ω-Conotoxin from Conus geographus; Ctx GVIA
EINECS	Contact for details

Quality Control

Our ω-Conotoxin Gvia is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Each batch is accompanied by comprehensive analytical data, including HPLC purity, mass spectrometry (MS) confirmation, and biological activity verification. Certificates of Analysis (COA) detailing all specifications are provided to guarantee reproducibility and reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Solubility	Soluble in water or aqueous buffers
Biological Activity (IC50)	Specified per batch (typically low nM range for N-type Ca2+ channels)
Endotoxin Level	< 1.0 EU/μg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.