Description

Penicillamine-Glutathione Mixed Disulfide is a stable, covalently bonded conjugate of two critical biological thiols, penicillamine and glutathione. This compound is of significant interest in biochemical research and pharmaceutical development due to its role in studying thiol-disulfide exchange mechanisms and oxidative stress pathways. It serves as a valuable reference standard and intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors.

Application

• Biochemical Research: Used as a reference standard and substrate in studies of thiol-disulfide exchange kinetics, redox biology, and enzyme mechanisms.
• Pharmaceutical Development: Acts as a key intermediate or analytical standard in the synthesis and quality control of drugs targeting oxidative stress or metal chelation.
• Metabolic Pathway Analysis: Employed to investigate glutathione metabolism and the biochemical role of penicillamine in cellular systems.
• Antioxidant Studies: Serves as a model compound for researching the protective effects of mixed disulfides against oxidative damage.
• Analytical Chemistry: Utilized as a high-purity calibrant in HPLC, LC-MS, and other chromatographic methods for quantifying thiols and disulfides.

Basic Information

Product Name	Penicillamine-Glutathione Mixed Disulfide
CAS No.	92000-26-5
Molecular Formula	C13H23N4O7S2
Molecular Weight	411.48 g/mol
Synonyms	L-Penicillamine-Glutathione Disulfide; (2S)-2-Amino-3-[[(2R)-2-amino-2-carboxyethyl]disulfanyl]-3-methylbutanoic acid; Glutathione-Penicillamine Mixed Disulfide; γ-Glu-Cys(Disulfide with Penicillamine)-Gly; D-Penicillamine and Glutathione Disulfide; N-(N-L-γ-Glutamyl-3-[(2-amino-2-carboxyethyl)disulfanyl]-L-cysteinyl)glycine; 3-[(2-Amino-2-carboxyethyl)disulfanyl]-L-cysteine derivative
EINECS	Contact for details

Quality Control

Our Penicillamine-Glutathione Mixed Disulfide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is easily oxidized; for long-term storage, consider under an inert atmosphere. Keep the container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.