Description

(Ser14)-Preangiotensinogen (1-14) (Human) is a synthetic peptide fragment corresponding to the first 14 amino acids of human angiotensinogen, with a serine residue at position 14. This specific sequence is a critical research tool for studying the renin-angiotensin system (RAS), which is fundamental to cardiovascular and renal physiology. It is primarily utilized by researchers and developers in pharmaceutical R&D, biochemistry, and clinical diagnostics for investigating hypertension, heart failure, and related metabolic disorders.

Application

• Biochemical Research: Used as a specific substrate for studying the enzymatic activity and kinetics of renin, the key enzyme in the RAS pathway.
• Pharmaceutical Development: Serves as a reference standard and key intermediate in the development and screening of novel renin inhibitors and other RAS-targeting therapeutics.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA) designed to measure angiotensinogen or its cleavage products in biological samples.
• Mechanistic Studies: Facilitates research into the molecular mechanisms of blood pressure regulation, electrolyte balance, and vascular remodeling.
• Cell Culture & In Vitro Models: Applied in cell-based assays to investigate the localized effects of the RAS in various tissues.
• Quality Control Standard: Acts as a high-purity standard for the quality assurance of related peptide products and diagnostic kits.

Basic Information

Item	Details
Product Name	(Ser14)-Preangiotensinogen (1-14) (Human)
CAS No.	91999-74-5
Molecular Formula	C66H103N19O20S
Molecular Weight	1490.7 g/mol
Synonyms	Human Angiotensinogen (1-14); Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser; Angiotensinogen Fragment 1-14; Ser14-Angiotensinogen (1-14); Preangiotensinogen (1-14); DRVYIHPFHLLVYS; RAS Research Peptide
EINECS	Contact for details

Quality Control

Our (Ser14)-Preangiotensinogen (1-14) (Human) is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.