Description

2-Chloropyrido[2,3-d]pyrimidine-4(1H)-thione is a high-value heterocyclic building block and key synthetic intermediate. This compound matters for its role as a versatile precursor in the development of novel pharmaceutical agents and agrochemicals, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for synthesizing target molecules with potential biological activity.

Application

• Pharmaceutical Intermediate: Serves as a critical scaffold for the synthesis of kinase inhibitors, anticancer agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators.
• Chemical Biology: Acts as a probe or building block for studying enzyme mechanisms and protein-ligand interactions.
• Material Science: Potential precursor for the synthesis of organic electronic materials and ligands for metal-organic frameworks (MOFs).
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring complex heterocycles.

Basic Information

Product Name	2-Chloropyrido[2,3-d]pyrimidine-4(1H)-thione
CAS No.	91996-76-8
Molecular Formula	C7H4ClN3S
Molecular Weight	197.64 g/mol
Synonyms	2-Chloro-1H-pyrido[2,3-d]pyrimidine-4-thione; 2-Chloro-4-mercaptopyrido[2,3-d]pyrimidine; 4(1H)-Pyrimidinethione, 2-chloropyrido[2,3-d]-; 2-Chloro-4-thioxo-3,4-dihydropyrido[2,3-d]pyrimidine; 91996-76-8; 2-Chloro-1H,4H-pyrido[2,3-d]pyrimidine-4-thione
EINECS	Contact for details

Quality Control

Our 2-Chloropyrido[2,3-d]pyrimidine-4(1H)-thione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.