Description

Ethyl 2-Hydroxypyrimidine-5-Carboxylate Hydrochloride is a high-purity organic salt derivative of a hydroxypyrimidine carboxylic acid ester, serving as a critical building block in advanced chemical synthesis. This compound is valued for its role as a versatile intermediate in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocyclic frameworks. The product, identified by CAS number 91978-81-3, is supplied with stringent quality control to ensure batch-to-batch consistency for demanding synthetic applications.

Application

• Pharmaceutical Intermediate: Key synthon for the research and production of novel drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the manufacture of advanced pesticides, herbicides, and fungicides that require pyrimidine-based active ingredients.
• Fine Chemical Production: Serves as a precursor for dyes, pigments, and other performance chemicals where the pyrimidine moiety imparts specific functional properties.
• Academic & Contract Research: Employed in laboratory-scale research for method development and exploring new synthetic pathways in organic and medicinal chemistry.
• Chemical Reference Standard: Can be utilized as a high-purity analytical standard for quality control and regulatory testing in API manufacturing.

Basic Information

Product Name	Ethyl 2-Hydroxypyrimidine-5-Carboxylate Hydrochloride
CAS No.	91978-81-3
Molecular Formula	C7H9N2O3·HCl
Molecular Weight	204.62 g/mol (Free base: 168.15 g/mol)
Synonyms	5-(Ethoxycarbonyl)-2-hydroxypyrimidine hydrochloride; Ethyl 5-carboxy-2-hydroxypyrimidine hydrochloride; 2-Hydroxypyrimidine-5-carboxylic acid ethyl ester hydrochloride; 2-Hydroxy-5-pyrimidinecarboxylic acid ethyl ester hydrochloride; 5-Carbethoxy-2-hydroxypyrimidine hydrochloride; Ethyl 2-oxo-1,2-dihydropyrimidine-5-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our Ethyl 2-Hydroxypyrimidine-5-Carboxylate Hydrochloride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing including HPLC, NMR, and IR spectroscopy to confirm identity and purity. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical parameters such as assay, impurity profile, and residual solvents. Our quality commitment ensures the material meets the high standards required for pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.