Description

(Nle27)-Grf (1-29) Amide (Human) CAS NO 91869-58-8 is a synthetic peptide analog of human growth hormone-releasing factor (GRF), specifically modified with Norleucine at position 27 and amidated at the C-terminus. This modification enhances its stability and biological activity, making it a critical research tool for studying growth hormone secretion and related endocrine pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on metabolic and growth disorders.

Application

• Biomedical Research: Fundamental studies on the mechanism of growth hormone (GH) release and the function of the GH-releasing hormone receptor (GHRHR).
• Drug Discovery & Development: Serving as a reference standard or active pharmaceutical ingredient (API) in preclinical research for novel therapeutics targeting growth deficiencies.
• Endocrinology Assays: Use in in vitro and in vivo bioassays to measure biological potency and screen for agonists or antagonists of the GH axis.
• Peptide Chemistry Studies: A model compound for investigating structure-activity relationships (SAR) due to its specific Norleucine substitution and amidation.
• Quality Control & Analytical Standards: Employed as a high-purity calibrant in analytical methods such as HPLC and mass spectrometry for peptide quantification and identification.

Basic Information

Product Name	(Nle27)-Grf (1-29) Amide (Human)
CAS No.	91869-58-8
Molecular Formula	C149H246N44O42
Molecular Weight	3359.8 g/mol
Synonyms	Norleucine27-hGRF (1-29)-NH2; [Nle27]hGRF(1-29) Amide; Growth Hormone-Releasing Factor (1-29), Human, Nle27-Amide; Somatoliberin (1-29), Norleucine27-, Amide; GHRH (1-29) (Human), [Nle27]-, Amide; GRF (1-29) (Human), Norleucine27-, Amide; [Nle27]-hGRF(1-29)NH2
EINECS	Contact for details

Quality Control

Every batch of (Nle27)-Grf (1-29) Amide (Human) is manufactured and analyzed under strict quality systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for research-grade peptides. Certificates of Analysis (COA) are available upon request, providing full transparency on purity, identity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.