Description

γ-(Pyroglutamyl-Glutamyl-Asparaginyl-Glycine)Amide is a synthetic tetrapeptide derivative with a pyroglutamyl N-terminus and a C-terminal amide. This specific molecular architecture is of significant interest for advanced research and development in life sciences. It is primarily utilized by biopharmaceutical and biochemical research organizations for applications in peptide synthesis, drug discovery, and as a reference standard. The compound's defined structure provides a critical building block for studying biological pathways and developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of more complex peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard or substrate in enzymatic studies, receptor binding assays, and metabolic pathway research.
• Drug Discovery & Development: Employed in high-throughput screening (HTS) and structure-activity relationship (SAR) studies to identify and optimize new drug candidates.
• Peptide Synthesis: A crucial raw material for solid-phase or solution-phase peptide synthesis (SPPS) to create custom peptides for various applications.
• Cosmeceutical R&D: Investigated for potential bioactive properties in the development of advanced skincare and anti-aging formulations.
• Diagnostic Reagent Development: Can be utilized in the design and production of peptide-based diagnostic kits and biomarkers.

Basic Information

Item	Detail
Product Name	γ-(Pyroglutamyl-Glutamyl-Asparaginyl-Glycine)Amide
CAS No.	91856-43-8
Molecular Formula	C19H28N6O9
Molecular Weight	484.46 g/mol
Synonyms	pGlu-Glu-Asn-Gly-NH2; Pyroglutamyl-glutamyl-asparaginyl-glycinamide; L-Pyroglutamyl-L-α-glutamyl-L-asparaginyl-glycine amide; 5-Oxo-L-prolyl-L-α-glutamyl-L-asparaginylglycinamide; Tetrapeptide pGlu-Glu-Asn-Gly-NH2; (5-Oxo-Pro)-Glu-Asn-Gly-NH2; L-Pyroglutamic Acid-L-Glutamic Acid-L-Asparagine-Glycine Amide
EINECS	Contact for details

Quality Control

Our γ-(Pyroglutamyl-Glutamyl-Asparaginyl-Glycine)Amide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral purity checks, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and decomposition. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.