Description

Grf (1-29) Amide (Rat) CAS NO 91826-20-9 is a synthetic peptide amide derivative of the growth hormone-releasing factor (GRF) sequence specific to rat models. This compound is of significant value for its role in endocrinology and metabolic research, serving as a critical tool for studying growth hormone secretion and regulation. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroendocrinology, peptide therapeutics, and metabolic disease studies.

Application

• Biomedical Research: Used as a reference standard and active agent in studies investigating the hypothalamic-pituitary-somatotropic axis and growth hormone (GH) release mechanisms in rat models.
• Pharmacology Studies: Employed in in vitro and in vivo assays to evaluate the potency, efficacy, and pharmacokinetics of GRF analogs and related peptide therapeutics.
• Endocrine Disorder Modeling: Applied in creating experimental models to understand diseases related to GH deficiency or excess, aiding in the development of diagnostic and therapeutic strategies.
• Peptide Chemistry & Development: Serves as a key intermediate or target molecule for the synthesis and structure-activity relationship (SAR) studies of novel GRF receptor agonists and antagonists.
• Cell Signaling Research: Utilized to stimulate GH secretion in primary pituitary cell cultures or cell lines to study intracellular signaling pathways (e.g., cAMP, calcium).
• Antibody Production: Can be used as an immunogen for generating specific antibodies against GRF (1-29) for immunoassay development.

Basic Information

Product Name	Grf (1-29) Amide (Rat)
CAS No.	91826-20-9
Molecular Formula	C140H220N44O39
Molecular Weight	3130.5 g/mol (theoretical)
Synonyms	Rat GRF (1-29) amide; Growth Hormone-Releasing Factor (1-29), rat, amide; rGRF (1-29)NH2; Somatoliberin (1-29), rat; Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2; rGRF-29; HP-228 (research code)
EINECS	Contact for details

Quality Control

Our Grf (1-29) Amide (Rat) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC for purity, MS for molecular weight confirmation, and amino acid analysis. We adhere to high standards suitable for research use, with purity typically exceeding 95% (by HPLC). Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Amino Acid Analysis	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.