Description

Z-n-Me-Dl-Ala-Oh Dcha is a protected amino acid derivative, specifically the dicyclohexylamine (DCHA) salt of N-benzyloxycarbonyl-N-methyl-DL-alanine. This compound serves as a crucial chiral building block and intermediate in sophisticated organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex peptide-based drugs and therapeutic agents.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the N-methyl-alanine residue, which can enhance metabolic stability and alter conformational properties.
• Protecting Group Strategy: The Z (Cbz) group provides temporary N-protection, while the DCHA salt form offers improved crystallinity and handling characteristics for purification.
• Academic & Industrial R&D: Essential for medicinal chemistry programs exploring structure-activity relationships (SAR) in bioactive molecules.
• Chiral Pool Synthesis: Serves as a source of a protected, N-methylated amino acid for the asymmetric synthesis of non-proteinogenic amino acids.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for target molecules in pilot plants and manufacturing.

Basic Information

Product Name	Z-n-Me-Dl-Ala-Oh Dcha
CAS No.	91738-83-9
Molecular Formula	C24H38N2O4
Molecular Weight	418.57 g/mol
Synonyms	N-Carbobenzyloxy-N-methyl-DL-alanine dicyclohexylamine salt; Cbz-N-methyl-DL-alanine DCHA salt; Z-N-methyl-DL-alanine dicyclohexylammonium salt; Nα-(Benzyloxycarbonyl)-N-methyl-DL-alanine dicyclohexylamine salt; N-Cbz-N-methyl-DL-alanine cyclohexylamine salt; (RS)-2-[(Benzyloxycarbonyl)(methyl)amino]propanoic acid - dicyclohexylamine (1:1); N-Methyl-N-(phenylmethoxy)carbonyl-DL-alanine dicyclohexylamine salt
EINECS	Contact for details

Quality Control

Our Z-n-Me-Dl-Ala-Oh Dcha is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure consistency and compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.