Description

1-(3-Hydroxy-4-(Hydroxymethyl)Cyclopentyl)-5-(2-Iodovinyl)-2,4-(1H,3H)-Pyrimidinedione is a sophisticated nucleoside analog with significant potential in advanced pharmaceutical research and development. This compound is valued for its unique structural features, including the iodovinyl group and the modified cyclopentyl sugar moiety, which are critical for probing biological mechanisms and developing targeted therapies. It serves as a key intermediate or active pharmaceutical ingredient (API) for researchers and manufacturers in the life sciences sector, particularly those focused on antiviral and anticancer drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Used as a probe or reference standard in studies involving DNA/RNA synthesis inhibition, enzyme kinetics, and cellular metabolism pathways.
• Antiviral Drug Development: Investigated for its potential activity against a range of viral targets due to its structural similarity to natural nucleosides.
• Oncology Research: Explored in preclinical studies for its cytostatic or cytotoxic properties against various cancer cell lines.
• Radiopharmaceutical Precursor: The iodine atom presents opportunities for radiolabeling (e.g., with I-125 or I-131) for diagnostic imaging or targeted radiotherapy research.
• Reference Standard: Employed in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.

Basic Information

Product Name	1-(3-Hydroxy-4-(Hydroxymethyl)Cyclopentyl)-5-(2-Iodovinyl)-2,4-(1H,3H)-Pyrimidinedione
CAS No.	91661-25-5
Molecular Formula	C12H13IN2O5
Molecular Weight	392.15 g/mol
Synonyms	5-(2-Iodovinyl)-1-[(1S,3R,4S)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]pyrimidine-2,4(1H,3H)-dione; (E)-5-(2-Iodovinyl)-2'-deoxyuridine; IVdU; (E)-5-(2-Iodoethenyl)-2'-deoxyuridine; 1-(3-Hydroxy-4-(hydroxymethyl)cyclopentyl)-5-[(E)-2-iodovinyl]uracil; Lodenosine impurity; Nucleoside analog 91661-25-5
EINECS	Contact for details

Quality Control

Our 1-(3-Hydroxy-4-(Hydroxymethyl)Cyclopentyl)-5-(2-Iodovinyl)-2,4-(1H,3H)-Pyrimidinedione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.