Description

1-(3-Hydroxy-4-(Hydroxymethyl)-Cyclopentyl)-5-(2-Bromovinyl)-2,4-(1H,3H)-Pyrimidinedione is a high-purity, nucleoside analog derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and intermediate for the synthesis of novel antiviral and anticancer agents. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleoside analog antiviral drugs.
• Antiviral Research: Investigated for activity against DNA viruses, including herpesviruses and hepatitis B virus (HBV).
• Oncology Research: Used as a scaffold for developing potential anticancer agents that target DNA replication.
• Biochemical Tool: Employed in enzymatic studies to understand polymerase inhibition mechanisms.
• Process Chemistry: Serves as a critical intermediate in the scale-up and optimization of active pharmaceutical ingredient (API) manufacturing processes.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	1-(3-Hydroxy-4-(Hydroxymethyl)-Cyclopentyl)-5-(2-Bromovinyl)-2,4-(1H,3H)-Pyrimidinedione
CAS No.	91661-22-2
Molecular Formula	C12H15BrN2O4
Molecular Weight	331.16 g/mol
Synonyms	5-(2-Bromovinyl)-1-[(1S,3R,4S)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]pyrimidine-2,4(1H,3H)-dione; (1S,3R,4S)-1-[5-(2-Bromovinyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-3-hydroxy-4-(hydroxymethyl)cyclopentane; BVarU; (‑)-5-(2-Bromovinyl)-1-[(1S,3R,4S)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]uracil; 5-(2-Bromovinyl)-1-[(1S,3R,4S)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]uracil; BVDU analog; Nucleoside analog intermediate; Antiviral intermediate.
EINECS	Contact for details

Quality Control

Our 1-(3-Hydroxy-4-(Hydroxymethyl)-Cyclopentyl)-5-(2-Bromovinyl)-2,4-(1H,3H)-Pyrimidinedione is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.