Description

(5'α,10α)-9,10-Dihydro-12'-Hydroxy-2'-Methyl-3',6',18-Trioxo-5'-(Phenylmethyl)-7',8'-Secoergotaman-8'-Oic Acid is a high-purity synthetic ergot alkaloid derivative, serving as a critical advanced intermediate in pharmaceutical research and development. Its complex, functionalized structure makes it an invaluable building block for the synthesis of novel therapeutic agents targeting neurological and cardiovascular systems. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and biotechnology industries, particularly those focused on developing next-generation treatments derived from ergot frameworks.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) with ergot-based structures.
• Neurological Research: Used as a reference standard and starting material in the development of compounds targeting serotonin, dopamine, and adrenergic receptors.
• Medicinal Chemistry: Serves as a sophisticated scaffold for structure-activity relationship (SAR) studies and the creation of novel chemical libraries for high-throughput screening.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for the production of specialized therapeutic agents.
• Analytical Standard: Used as a high-purity certified reference material (CRM) for method development, validation, and quality control in analytical laboratories.
• Academic Research: Utilized in university and institutional labs for studying the chemistry, biochemistry, and pharmacology of ergot alkaloids.

Basic Information

Product Name	(5'α,10α)-9,10-Dihydro-12'-Hydroxy-2'-Methyl-3',6',18-Trioxo-5'-(Phenylmethyl)-7',8'-Secoergotaman-8'-Oic Acid
CAS No.	91653-37-1
Molecular Formula	C32H35N3O6
Molecular Weight	557.64 g/mol
Synonyms	9,10-Dihydro-12'-hydroxy-2'-methyl-3',6',18-trioxo-5'-(phenylmethyl)-7',8'-secoergotaman-8'-oic acid; 7',8'-Secoagroclavine-8'-carboxylic acid derivative; Lysergol derivative, seco-; 8'-Carboxy-7',8'-secoergotaman; (5'alpha,10alpha)-Dihydro-12'-hydroxy-2'-methyl-3',6',18-trioxo-5'-(phenylmethyl)-7',8'-secoergotaman-8'-oic Acid; Ergotaman-8'-oic acid, 9,10-dihydro-12'-hydroxy-2'-methyl-3',6',18-trioxo-5'-(phenylmethyl)-7',8'-seco-, (5'α,10α)-
EINECS	Contact for details

Quality Control

Our (5'α,10α)-9,10-Dihydro-12'-Hydroxy-2'-Methyl-3',6',18-Trioxo-5'-(Phenylmethyl)-7',8'-Secoergotaman-8'-Oic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.