Description

Memantine Hcl CAS NO 41100-52-1 is a high-purity pharmaceutical active ingredient, specifically the hydrochloride salt of memantine, a well-characterized NMDA receptor antagonist. This compound is critical for the formulation of medications used to treat moderate to severe Alzheimer's disease, offering a mechanism to regulate glutamate activity in the brain. It is essential for pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in neurology-focused drug development and production.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of prescription medications for Alzheimer's disease and other neurological disorders.
• Neurological Research: Serves as a key reference standard and tool compound in preclinical studies investigating NMDA receptor function and neuroprotection.
• Generic Drug Manufacturing: Sourced by generic pharmaceutical companies for the production of bioequivalent versions of branded memantine medications.
• Clinical Trial Material: Used in the manufacturing of dosage forms for Phase I-III clinical trials for new neurological indications.
• Veterinary Pharmaceutical Research: Investigated for potential applications in cognitive dysfunction syndrome (CDS) in aged pets.

Basic Information

Product Name	Memantine Hydrochloride
CAS No.	41100-52-1
Molecular Formula	C12H21N·HCl
Molecular Weight	215.76 g/mol
Synonyms	Memantine HCl; 1-Amino-3,5-dimethyladamantane hydrochloride; 3,5-Dimethyl-1-adamantanamine hydrochloride; DMAA hydrochloride; Akatinol; Ebixa; Namenda; Axura; MAR-01; MRZ 2/579
EINECS	Contact for details

Quality Control

Our Memantine Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure compliance with relevant pharmacopeial standards (e.g., USP, EP) for pharmaceutical intermediates and APIs. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for identity, purity, assay, and specified impurities. We support our clients' regulatory submissions with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.15% Total impurities: ≤ 0.5%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.