Antiparkinsonian Drugs
Antiparkinsonian Drugs
Antiparkinsonian drugs are designed to correct the dopaminergic–cholinergic imbalance that underlies motor dysfunction in Parkinson’s disease and related movement disorders. Key drug classes include dopamine precursors such as levodopa, dopamine agonists, MAO-B inhibitors, COMT inhibitors, anticholinergics, and adenosine A2A antagonists. These agents work by enhancing dopamine synthesis, prolonging dopamine availability, stimulating dopamine receptors, or counteracting excessive cholinergic activity in the striatum. Antiparkinsonian medications improve bradykinesia, rigidity, tremor, and overall motor performance, thereby enhancing patient independence and quality of life. Long-term therapy requires optimization to minimize complications such as dyskinesias, motor fluctuations, and neuropsychiatric effects. These drugs remain central to symptomatic management while emerging therapies continue to target neuroprotection and disease modification.
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