Description

Amantadine Formate is the formic acid salt of the antiviral and antiparkinsonian agent amantadine. This salt form is often utilized to enhance the stability, solubility, or bioavailability of the active pharmaceutical ingredient for formulation purposes. It is a critical intermediate and reference standard in the research, development, and quality control of pharmaceutical products. Key industries that require this compound include pharmaceutical manufacturing, contract research organizations (CROs), and academic research institutions.

Application

• Pharmaceutical Intermediate: Serves as a key salt form in the synthesis and formulation of final drug products containing amantadine.
• Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control testing in compliance with pharmacopeial standards (e.g., USP, EP).
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the production of antiviral and antiparkinsonian medications.
• Biochemical Research: Utilized in preclinical and clinical studies to investigate the pharmacokinetics, metabolism, and mechanism of action of amantadine derivatives.
• Formulation Development: Acts as a stable salt form for creating various dosage forms, improving the physical and chemical properties of the drug substance.

Basic Information

Product Name	Amantadine Formate
CAS No.	16790-64-0
Molecular Formula	C11H19NO2
Molecular Weight	197.27 g/mol
Synonyms	1-Adamantanamine formate; Adamantan-1-amine formate; Amantadine formic acid salt; 1-Aminoadamantane formate; Formic acid, compd. with 1-adamantanamine (1:1); Trivalentine formate; PK-Merz salt
EINECS	Contact for details

Quality Control

Our Amantadine Formate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and composition. We provide full traceability and support regulatory submissions with comprehensive documentation. Certificates of Analysis (COA) are available upon request, detailing results against relevant pharmacopeial standards (USP/EP) or custom specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider conditions recommended for hygroscopic and light-sensitive pharmaceutical intermediates.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.