Description

Enkephalin-Leu, Dehydro-Phe(4)- CAS NO 91549-05-2 is a synthetic, modified peptide analog of the endogenous opioid peptide enkephalin, featuring a dehydro-phenylalanine residue at position 4. This structural modification is critical for enhancing metabolic stability and receptor selectivity, making it a valuable tool for advanced neuropharmacological research. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on central nervous system (CNS) drug discovery and peptide-based therapeutic development.

Application

• Neuroscience Research: As a key reference standard and probe for studying δ-opioid receptor (DOR) interactions, signal transduction, and ligand binding assays.
• Drug Discovery & Development: Serving as a lead compound or intermediate in the design of novel, non-addictive analgesics and neuroprotective agents with improved pharmacokinetic profiles.
• Biochemical Assays: Used in competitive binding studies, enzyme inhibition tests, and functional assays to elucidate the structure-activity relationships (SAR) of opioid peptides.
• Academic & Clinical Research: Investigating the physiological roles of enkephalins in pain modulation, mood regulation, and neuroendocrine functions.
• Peptide Chemistry Studies: A model compound for studying the effects of introducing non-natural amino acids (dehydro-amino acids) on peptide conformation, stability, and biological activity.

Basic Information

Product Name	Enkephalin-Leu, Dehydro-Phe(4)-
CAS No.	91549-05-2
Molecular Formula	C30H38N6O7
Molecular Weight	594.66 g/mol
Synonyms	[Leu5]-Enkephalin, Dehydro-Phe(4)-; Dehydro-Phe4-Leu5-Enkephalin; H-Tyr-Gly-Gly-δPhe-Leu-OH; δPhe4-Leu5-Enkephalin; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-[(1E)-3-phenylprop-1-en-1-yl]amino]-4-methylpentanoic acid; Dehydrophenylalanine4-Leucine5-Enkephalin; Opioid peptide analog 91549-05-2
EINECS	Contact for details

Quality Control

Our Enkephalin-Leu, Dehydro-Phe(4)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure structural integrity. Certificates of Analysis (COA) detailing purity, water content, and related substances are provided and available upon request, supporting compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.