Description

Cystatin C CAS NO 91448-99-6 is a low molecular weight protein and a potent inhibitor of cysteine proteases. It serves as a critical biomarker for assessing kidney function, offering a more reliable alternative to serum creatinine in many clinical scenarios. This high-purity biochemical is essential for research institutions, diagnostic kit manufacturers, and pharmaceutical companies developing novel therapeutics and in-vitro diagnostics (IVD).

Application

• Clinical Diagnostics: Primary calibrator and reference standard in immunoassays for the precise quantification of serum cystatin C levels to estimate glomerular filtration rate (GFR).
• Biomedical Research: Used in studies investigating the role of cysteine proteases and their inhibitors in physiological and pathological processes, including cancer, neurodegenerative diseases, and inflammation.
• IVD Kit Production: A key raw material in the manufacture of ELISA kits, chemiluminescence assays, and other diagnostic platforms for renal function testing.
• Therapeutic Development: Investigated for its potential therapeutic applications in conditions involving uncontrolled proteolysis, such as arthritis and certain cardiovascular diseases.
• Quality Control: Employed as an internal standard in laboratory quality control procedures to ensure the accuracy and reproducibility of diagnostic test results.

Basic Information

Item	Detail
Product Name	Cystatin C
CAS No.	91448-99-6
Molecular Formula	Contact for details
Molecular Weight	~13.4 kDa
Synonyms	Cystatin 3; CST3; Post-γ-Globulin; Neuroendocrine Basic Polypeptide; γ-Trace Protein; Human Cystatin C; Cysteine Protease Inhibitor C; 2-HS Glycoprotein Inhibitor
EINECS	Contact for details

Quality Control

Our Cystatin C is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive diagnostic and research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identity (by mass spectrometry), endotoxin levels, and biological activity. We adhere to ISO 13485 quality management principles relevant for IVD raw material manufacture.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Conforms
Purity (HPLC)	≥ 95%
Assay (Immunological)	≥ 98% of stated value
Endotoxin	< 1.0 EU/μg
Biological Activity	Fully active as a cysteine protease inhibitor
Solubility	Soluble in water or PBS, pH 7.4

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.