Description

Spike Glycoprotein, Coronavirus is a critical viral surface protein responsible for host cell receptor recognition and membrane fusion. This recombinant protein is essential for research and development in virology, immunology, and therapeutic discovery. It is primarily utilized by pharmaceutical companies, diagnostic manufacturers, and academic research institutions for vaccine development, serological assay production, and neutralizing antibody studies.

Application

• Vaccine Research & Development: Key antigen for immunogenicity studies and vaccine candidate evaluation.
• Diagnostic Assay Development: Used as a coating or detection antigen in ELISA, lateral flow, and other immunoassays for antibody detection.
• Therapeutic Antibody Screening: Critical target for the discovery and characterization of monoclonal antibodies and antiviral drugs.
• Structural Biology Studies: Employed in X-ray crystallography and cryo-electron microscopy to understand viral entry mechanisms.
• Virology & Pathogenesis Research: Fundamental tool for studying virus-host interactions, tropism, and infection pathways.
• Quality Control & Standardization: Serves as a reference standard for calibrating diagnostic tests and ensuring batch-to-batch consistency in vaccine production.

Basic Information

Product Name	Spike Glycoprotein, Coronavirus
CAS No.	107476-75-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	SARS-CoV-2 Spike Protein; S Glycoprotein; Coronavirus Spike Protein; 2019-nCoV Spike Protein; COVID-19 Spike Antigen; S Protein; Trimeric Spike Glycoprotein; Receptor-Binding Domain (RBD) Source Protein
EINECS	Contact for details

Quality Control

Our Spike Glycoprotein is produced under stringent conditions and undergoes rigorous analytical testing to ensure high purity, correct conformation, and biological activity. Each batch is characterized using a suite of techniques including SDS-PAGE, size-exclusion chromatography (SEC), and endotoxin testing. Certificates of Analysis (COA) detailing purity, concentration, and functional data are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted protein aliquots should be stored at -70°C to -80°C and avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	> 90%
Identification (Western Blot)	Positive
Endotoxin Level (LAL)	< 1.0 EU/µg
Protein Concentration	Provided on COA
Biological Activity (e.g., ACE2 binding)	Confirmed by ELISA/SPR
Buffer Composition	Provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.