Description

p-Nh2-Bn-Dtpa(B-300) is a bifunctional chelating agent, a derivative of diethylenetriaminepentaacetic acid (DTPA) featuring a para-aminobenzyl (PAB) linker. This molecular architecture is critical for creating stable, site-specific conjugates with biomolecules, enabling targeted delivery of diagnostic or therapeutic metal ions. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing advanced radiopharmaceuticals, MRI contrast agents, and targeted cancer therapies. The compound, identified by CAS No. 102650-29-3, is a key intermediate in the synthesis of precision medical agents.

Application

• Radiopharmaceutical Precursor: Conjugation to antibodies, peptides, or small molecules for labeling with diagnostic (e.g., 99mTc, 68Ga, 111In) or therapeutic (e.g., 177Lu, 90Y) radionuclides.
• MRI Contrast Agent Development: Chelation of gadolinium (Gd3+) or other paramagnetic ions to create targeted contrast agents for enhanced imaging.
• Targeted Drug Delivery Systems: Construction of bioconjugates where the chelator-metal complex is linked to a targeting moiety for site-specific action.
• Research Chemical: Used in chemical biology and inorganic chemistry research to study metal-ligand interactions and develop novel chelation platforms.
• Diagnostic Kit Formulation: A key component in the development of in-vitro diagnostic kits requiring stable metal ion complexes.

Basic Information

Product Name	p-Nh2-Bn-Dtpa(B-300)
CAS No.	102650-29-3
Molecular Formula	C26H32N4O10 • (xH2O)
Molecular Weight	560.55 g/mol (anhydrous basis)
Synonyms	2-[Bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid, 4-aminobenzyl ester; p-Aminobenzyl-DTPA; DTPA-PAB-NH2; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid mono(4-aminobenzyl) ester; B-300 DTPA derivative; NH2-Bn-DTPA; DTPA-benzyl-amine; Para-aminobenzyl-diethylenetriaminepentaacetic acid
EINECS	Contact for details

Quality Control

Our p-Nh2-Bn-Dtpa(B-300) is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and other critical parameters is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.