Description

4-Chloro-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazolo[3,4-D]Pyrimidine is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyrimidine class of heterocyclic compounds. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly kinase inhibitors used in targeted cancer therapies. It is essential for research and development laboratories, process chemists, and manufacturers in the pharmaceutical and biotechnology sectors seeking reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step production of potent kinase inhibitor drugs for oncology applications.
• Biochemical Research: Used as a core scaffold in medicinal chemistry for the design and synthesis of novel therapeutic agents targeting specific enzymes and receptors.
• Process Development & Scale-up: Serves as a critical material for optimizing synthetic pathways from laboratory scale to commercial manufacturing.
• Contract Manufacturing (CMO/CDMO): Supplied to contract development and manufacturing organizations for the production of client-specific APIs under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) and developing new chemical entities.

Basic Information

Product Name	4-Chloro-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazolo[3,4-D]Pyrimidine
CAS No.	91446-15-0
Molecular Formula	C10H11ClN4O
Molecular Weight	238.67 g/mol
Synonyms	4-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine; 4-Chloro-1-(tetrahydropyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine; 1-(Oxan-2-yl)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine; 4-Chloro-1-(2H-tetrahydropyran-2-yl)pyrazolo[3,4-d]pyrimidine; THP-protected 4-chloropyrazolopyrimidine; 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine, 1-(tetrahydro-2H-pyran-2-yl)-; CAS 91446-15-0
EINECS	Contact for details

Quality Control

Our 4-Chloro-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazolo[3,4-D]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the stringent requirements for pharmaceutical intermediate use. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.